AISHILA KAR, AMITY UNIVERSITY KOLKATA
Catalysts are extensively used in the production of chemicals and pharmaceutical products. They have the great significance of nanocatalysts in different areas of nanotechnology such as nanochemistry, nanopharmaceuticals, and nanomedicine. Also, developed for cancer treatment based on nanoparticles (NPs) which promote Fenton reaction have been widely used by scientists. Magnetic nanoparticles can serve as catalysts in the production of heterocyclic compounds with potential anticancer properties.
Heterocyclic compounds have been used as an important portion in the production of anticancer drugs. Yet, there’s a need for developing inexpensive and complex chemical-based catalysts for large-scale production of heterocyclic compounds. The huge application of magnetic nano catalysts obtains from the fact that these agents have provided very successful outcomes in the production of heterocyclic compounds as potential anticancer drugs. In fact, magnetic nano catalysts either with or without NPs molecules can be used as multiple promising nano catalysts in production of heterocyclic compounds based on magnetic NPs-catalysed reactions.
Concerning in cancer therapy the challenges of nano catalyst, noted that the intracellular level of H2O2 in cancer cells should be increased in synthesis of a large amount of OH• to inspire promising catalytic performance of nano catalysts. Therefore, some planning like combination of magnetic nano catalysts with different origin of H2O2 production should be developed. Magnetic NPs with distinct physicochemical properties synthesized in a number of ways can be used as effective catalysts for reactions to produce heterocyclic compounds as potential anticancer drugs.
Pharmaceutical companies should give it a try to control these drawbacks by assemble nano catalysts like conjugation with other NPs or with natural compounds.
Also read: CRISPR-Cas9 Therapy to Cure Sickle cell anaemia
SOURCE- Magnetic nano catalysts as multifunctional platforms in cancer therapy through the synthesis of anticancer drugs and facilitated Fenton reaction https://doi.org/10.1016/j.jare.2020.12.001
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