-Binayak Das, Team Bioxone
A new study has revealed the presence of a unique class of T cells, known as the Memory CD8 T lymphocytes, in mice, and its analogous population in humans also. This class of memory cells exhibited combined molecular functioning characteristic features, of both short-lived effector cells and long-lived memory T cells.
They differ from the general class of effector memory (TEM) cells and central memory (TCM) cells, in terms of transcription, function, development and differentiation (they are terminally differentiated).
Memory CD8 T cells have shown to provide robust protection against a variety of intracellular pathogens. The study further reported the need for demarcation of the terminal-TEM cells from the already-defined class of TEM cells. Factors contributing to their unique features include their improved presence in lymphoid tissues, enhanced IL-2 biogenesis and recall potential, improved homeostatic activity, superior transcription factor needs, and their exclusive molecular phenotype.
The study urged the need for redefining the classification of TEM biology, to broaden the existing suggestions, improving the overall understanding of how memory cells differ from each other, based on their functions and roles. Achieving such clarity in their immunological memory can ultimately lead to improved immunotherapies.
Source: Milner, J. Justin, et al. “Delineation of a Molecularly Distinct Terminally Differentiated Memory CD8 T Cell Population.” Proceedings of the National Academy of Sciences, Sept. 2020. https://www.pnas.org/content/early/2020/09/24/2008571117
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