Shreyas bhat, DY Patil School of biotechnology and bioinformatics Rhonda Voskuhl a post-doctoral student at the national institute of health united states in mid-1990 observed the sex discrepancy for multiple sclerosis is twice in women as compared to men. Multiple Sclerosis is an infection that affects the cerebrum & central nervous system. What are autoimmune […]
Sayak Banerjee, Amity University Kolkata Autoimmune Hepatitis and Autoimmune sclerosing cholangitis Autoimmune hepatitis (AIH) is a complex disease that occurs in patients of all ages present in both acute and chronic forms. Having no disease-specific test, it is a diagnosis of exclusion with one-third of patients suffering from advanced liver disease. Autoimmune sclerosing cholangitis (ASC) […]
PRAGYA SANTRA, AMITY UNIVERSITY Genome-wide association studies (GWAS) mapped the T-cell stimulatory pathways along with the CD28, CTLA4, and ICOS genes. GWAS studies and autoimmune disorders identified enriched chromatin regions as a consequence of memory T-cell over-activation. T-cell stimulation after occurring in the secondary lymphoid delivers two signals, first via T-cell receptors (TCR) to recognize […]
Rohit Bhattacharjee, Amity University Kolkata Although inhibition of T cell co-inhibitory receptors has brought about cancer therapy, mechanisms governing their expression on human T cells have not been explained. Type 1 interferon (IFN-I) regulates T cell immunity in viral infection, autoimmunity, cancer, and may enhance induction of T cell exhaustion in chronic viral infection. To […]
Shreyasi Panja, IQ City Medical College Paul Ehrlich, first introduced the concept of autoimmunity and termed it as “horror autotoxicus “, because the body’s own immunologically competent cells or antibodies act against its self-antigens resulting in structural and functional damage. Immunological tolerance is a state in which an individual is incapable of developing an […]
