Aishila Kar, Amity University Kolkata
Hypertension, along with difficulties like stroke and chronic kidney disease, consumes social and medical wealth. Around 43% of cardiovascular incidents were found to be assigned to hypertension. Haemoglobin glycation index (HGI) is observed to be a convenient measurable indicator to evaluate the individual difference of HbA1c. In the current study, among Chinese individuals, it has been tested the relationship between HGI and the risk of hypertension.
This work was a community-based survey that took place in Longzihu, Bengbu, China. Using a stratified multi-stage cluster sampling method eligible candidates were selected. HGI was measured as “HbA1c-predicted HbA1c” and divided into four parts according to quartile. The following parts were used to evaluate interactive effects: (1) relative excess risk for interaction (RERI); (2) attributable proportion for interaction (AP); and (3) synergy index (SI). Statistical analysis was present using R software.
In this survey, 1777 eligible candidates were selected with an average age was 60.82 ± 11.24 years. 433 subjects (24.4%) among the respondents, were found to have hypertension. From Q1 to Q4, an increase in the prevalence of hypertension of HGI was noticed (p < 0.001). The multivariable logistic model showed that subjects at the highest HGI group had an increased risk of being hypertensive than the first quartile of HGI, as indicated by the OR value of 1.87. Again, a significant interaction between family background of hypertension and HGI on hypertension risk was noticed. The interactive effect between abdominal obesity and HGI was also found to be important.
In conclusion, high HGI was independently related to the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family background of hypertension that increased the risk of hypertension. For now, exploring the processes that cause variation of HbA1c levels may introduce effective novel plans in the early stoppage of hypertension and low blood pressure.
SOURCE- Association of haemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey Jing Mi1†, Jian Song1†, Yingying Zhao2 and Xuesen Wu
Mi et al. BMC Cardiovasc Disord (2020) 20:477 https://doi.org/10.1186/s12872-020-01762-0
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