Shrestha Dutta, Amity University Kolkata
Non-alcoholic fatty liver disease (NAFLD) is the most quickly spreading chronic liver sickness. It is closely identified with metabolic disorder and its related conditions, including obesity, type 2 diabetes, dyslipidemia, hypertension, and hyperuricemia. Past studies have uncovered a connection between hyperuricemia and the seriousness of liver damage in NAFLD. A biopsy-based analysis has shown that hyperuricemia is related to the seriousness of steatosis, lobular infection, and nonalcoholic fatty liver disease activity score (NAS). Obesity is a dangerous factor for the development of NAFLD.
Recent studies uncover that body mass index (BMI) is a significant factor in the study of uric acid and metabolic diseases. According to the studies, researchers show that uric acid has no impact on the risk of ischemic heart disease and blood pressure. Hence, it is important to consider obesity to find the relation between hyperuricemia and NAFLD, especially in liver fibrosis. The goal of this research was to study whether obesity can alter the relationship between serum uric acid and the seriousness of liver damage in NAFLD, and the interactive impact of hyperuricemia and obesity.
Taking into account, BMI is a significant element in the study of uric acid and metabolic diseases, the relationship between hyperuricemia and the severity of NAFLD was additionally found in non-obese and obese people. Surprisingly, the relation was essentially changed in various BMI groups. In non-obese people, scientists found no proof of the relationship of hyperuricemia with either severe hepatic steatosis, raised ALT, or progressed fibrosis. Conversely, hyperuricemia was related to higher chances of both severe hepatic steatosis, raised ALT, and advanced fibrosis in obese NAFLD.
The outcomes uncovered that hyperuricemia was related to the seriousness of liver damage in obese NAFLD, not in non-obese people. Also, hyperuricemia and obesity had an essentially synergistic impact on hepatic steatosis and fibrosis. Hence, the board of uric acid should be focused on obese NAFLD.
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Reference :Obesity interacts with hyperuricemia on the severity of non-alcoholic fatty liver disease– Mimi Zhou et al,
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