Shrestha Dutta, Amity University Kolkata
COVID-19 brought about by severe acute respiratory syndrome Covid 2 (SARS-CoV-2), is a worldwide pandemic that has brought about more than 100 million infections and over 2 million death. Researches demonstrate that residual radiologic abnormalities caused due to SARS and MERS (middle east respiratory syndrome) lead to damage of the pulmonary functions which lasts for a few months or years. In contrast with SARS-CoV-1 and MERS-CoV, COVID-19 is a profoundly infectious disease with less severity. With a large number of affirmed cases worldwide, understanding the recuperation dynamics in the COVID-19 released patients will be instrumental in identifying the patient prognosis.
How was the study conducted?
A potential cohort study of patients suffering from COVID-19 was done. Chest CT scan results were evaluated during hospitalization and at 2 weeks, 1 month, 3 months, 6 months, and a year post-discharge from hospital. A standardized technique was applied to all radiographic assessments with similar CT equipment. Two radiologists with more than 5-year experience assessed the CT scan images as demonstrated earlier. Each lung was separated into three zones:
- superior (above carina)
- middle (beneath carina to the inferior pulmonary vein)
- inferior (below to inferior pulmonary vein)
Risk factors associated with residual CT opacities and the impact of residual CT abnormalities on pulmonary capacities at 1 year were assessed.
The outcome of the study:
Total of 41 patients was assessed in this examination. Continuous recovery after release from the hospital was affirmed by the sequential CT scores. Around 47% of the patients showed remaining distortion on pulmonary CT scan with a median CT score of 0 (interquartile range (IQR) of 0–2) at 1 year after release. The ground-glass opacity (GGO) with a reticular arrangement as the major radiologic design was also observed.
Patients with residual radiological anomalies were older (p = 0.01) with:
- higher rate in smokers (p = 0.04)
- higher in hypertensives (p = 0.05)
- lower SaO2 (p = 0.004)
- higher pervasiveness of auxiliary bacterial diseases during acute stage (p = 0.02).
The reduced residual volume (p < 0.001) and pulmonary functions of total lung capacity (p = 0.008) in patients with residual CT anomalies and were adversely corresponded with CT scores.
Significance of the study:
Coronavirus survivors showed gradual enhancement for lung CT scans during 1-year recuperation. Residual sores may be seen in pneumonic radiography and corresponded with lung volume parameters. Old patients are at high risk of creating residual CT irregularities. Investigation offers a thorough comprehension of the longitudinal lung changes in COVID-19 patients during the acute and convalescent periods, which could help in giving the theoretical basis to recovery.
Also read: Matisse: a new tool for tissue and cell sequence profiling
Reference:
- Chen, Y., Ding, C., Yu, L., Guo, W., Feng, X., Yu, L., Su, J., Xu, T., Ren, C., Shi, D., Wu, W., Yi, P., Liu, J., Tao, J., Lang, G., Li, Y., Xu, M., Sheng, J., Li, L., & Xu, K. (2021). One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection. BMC Medicine, 19(1), 191. https://doi.org/10.1186/s12916-021-02056-8
- The Corrosion Prediction from the Corrosion Product Performance
- Nitrogen Resilience in Waterlogged Soybean plants
- Cell Senescence in Type II Diabetes: Therapeutic Potential
- Transgene-Free Canker-Resistant Citrus sinensis with Cas12/RNP
- AI Literacy in Early Childhood Education: Challenges and Opportunities
Author info:
Shrestha Dutta is a 4th-year Biotechnology Engineering Student with a great interest in Genetics, Recombinant DNA Technology, and Immunology. She is a creative scientific writer in Bioxone with an inclination towards gaining knowledge regarding various sections of Biotechnology and engaging herself in various wet lab skills. She also has a review paper publication in the journal IJSER.
Reference links:
Publications at Bioxone:
Y chromosome in the little guppy fish: How did it evolve?
Vaishnavi Kardale, Bioinformatics Centre, Savitribai Phule Pune University A eukaryotic cell can divide in two ways- either by mitosis or by meiosis. Mitosis leads to the formation of daughter cells identical to parent cells. While meiosis leads to the generation of daughter cells that are different from the parent cells. These differences are brought about […]