SRILAGNA SARKAR, AMITY UNIVERSITY
One of the deadliest and diagnosed diseases in the world is colon cancer. Though the last few decades have seen an improvement in colon cancer with routine screening and early detection, despite all these it still claims thousands of lives every year. The current treatments for colon cancer are through surgery and chemotherapy but these also come with exposure to toxicity. Therefore, there is urgency in demand of better therapeutics.
Plants are a great potential source of novel therapeutics, nearly 50% of current chemotherapeutic drugs come from isolated medicinal plants. A review has found Eclipta alba to possess anticancer potentials along with many other pharmacological activities. The phytochemicals of Eclipta alba were extracted from shaded dried plants, where methanol was used as a solvent. Its anticancer effects were investigated through various cancer cells including normal human lung fibroblast cells using MTT (methythiazol diphenyltetrazolium bromide) assay, and migration. Final results were analyzed using ANOVA and Dunnetts’s test. MTT assay revealed the methanolic extract of Eclipta alba, showed significant specificity against HCT-116 (human colorectal carcinoma) compared to other cancer cells. The migration and the colonogenic assays also confirmed the anticancer potential of Eclipta alba extract against HCT-116 cells along with nontoxicity WI-38 cells.
Because no such anticancer activity of this kind has been previously reported, this stands as a unique finding of its kind. With minimal or non toxicity effect it also opens up a great possibility to develop an antitumor drug candidate against the deadly colon cancer in near future.
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ICAR-NATIONAL DAIRY RESEARCH INSTITUTE
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