Ayooshi Mitra, Amity University Kolkata
To avert the spread of the pandemic of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a successful vaccine is needed. In an examination directed recently, safety, tolerability, and neutralizer reaction information from an on-going placebo-controlled treatment observer-blinded phase 1/2 coronavirus disease 2019 (COVID-19) vaccine trial BNT162b1, a lipid nanoparticle (LNP) nucleoside-modified messenger RNA (mRNA) encoding the SARS-CoV-2 spike protein1 receptor-binding domain (RBD) was accounted for. Here, antibody and T-cell responses following BNT162b1 vaccination in a second, non-randomized, Phase 1/2 open-label trial in healthy adults aged 18-55 years were presented.
Two dosages of 1 to 50 μg of BNT162b1 brought strong CD4 + and CD8 + T-cell and antibody responses, with RBD-binding IgG concentrations clearly above those in the COVID-19 sample (HCS) panel. For the 43rd day of SARS-CoV-2 serum neutralizing, mean values were 0.7-fold (1 μg) to 3.5-fold (50 μg) of the HCS panel. Immune sera broadly neutralized pseudoviruses with various SARS-CoV-2 spike variants. Most participants had positive T cell immune responses with CD8 + RBD-specific and CD4 + T-cell development. The tough RBD-specific antibody, T-cell, and favourable cytokine reactions induced by the BNT162b1 mRNA vaccine suggest multiple advantageous mechanisms with the potential to defend against the COVID-19.
References: Sahin, U., Muik, A., Derhovanessian, E. et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses. Nature (2020). https://doi.org/10.1038/s41586-020-2814-7 https://www.nature.com/articles/s41586-020-2814-7
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