–Arpita Adhikary, Amity University Kolkata
When the 21st century is facing pandemic, it is reported that Dengue and coronavirus share almost similar clinical features that cannot be discriminated. There are few independent research studies that observed false-positive tests for coronavirus.
In Singapore, two false-positive results from rapid serological testing for dengue was later confirmed to have COVID-19. 57-year-old man & woman with no medical and travel history got a positive result for dengue but due to bad health, a chest radiograph was done for SARS-CoV-2 via RT-PCR from nasopharyngeal swab, which returned positive.
In CSIR-IICB, five out of thirteen dengue antibody-positive serum samples showed false-positive results in SARS-CoV-2 in 2017. In Israel serum samples of 55 people were taken for SARS-CoV-2 infection, also undergo an ELISA test for assessment of serology status in patients with dengue. After analysis, 12 (21%) positive cases were detected. Though it is not expected to show false positive results as these viruses come from different families so there is a chance of cross-reactivity between dengue and SARS-COVID 19.
Reference:
- Dengue antibodies can cross-react with SARS-CoV-2 and vice versa-Antibody detection kits can give false-positive results for both viruses in regions where both COVID-19 and Dengue co-exist, Himadri Nath, Abinash Mallick, Subrata Roy, Soumi Sukla, Keya Basu, Abhishek De, Subhajit Biswas
doi: https://doi.org/10.1101/2020.07.03.20145797
- Covert COVID-19 and false-positive dengue serology in Singapore, Gabriel Yan,a Chun Kiat Lee,b Lawrence T M Lam,c Benedict Yan,b Ying Xian Chua,c Anita Y N Lim,a Kee Fong Phang,a Guan Sen Kew,a Hazel Teng,a Chin Hong Ngai,a Li Lin,d Rui Min Foo,d Surinder Pada,d Lee Ching Ng,e and Paul Anantharajah Tambyaha,Lancet Infect Dis. 2020;20(5):536. doi:10.1016/S1473-3099(20)30158-4,
- Potential antigenic cross-reactivity between SARS-CoV-2 and Dengue viruses, Yaniv Lustig, Shlomit Keler, Rachel Kolodny,Nir Ben-Tal, Danit Atias-Varon, Ekaterina Shlush, M.D, Motti Gerlic, Ariel Munitz, Ram Doolman, Keren Asraf, Liran I Shlush, M.D., Asaf Vivante, M.D.,,Clinical Infectious Diseases, 2020, ciaa1207, https://doi.org/10.1093/cid/ciaa1207
CNCI JRF Job Openings | Chittaranjan National Cancer Institute
–Shristi Sharma, Team bioXone CNCI JRF Job Openings – Chittaranjan National Cancer Institute has called applications for Junior Research Fellow Vacancy. Interested and eligible candidates can check out all of the details on the same below: Advertisement No. 607/2020 A virtual online interview will certainly be held on 25th September 2020, 11 a.m. for two […]