Camelia Bhattacharyya, Amity University Kolkata
The heme group is a very important biomolecular group for the functioning of the body. From the transfer of oxygen to different parts of the body to the reduction of oxygen, transfer of electrons and other important functions, it is one of the key molecules for most of the living cells. But can it also help in a detailed study of the antibiotics in order to take medical science to a step further? Let us see.
In a very recent study conducted by a group of scientists in France, a demonstration was shown in which several antibodies contained specific traits of antigen-binding regions in their sequences. This led to the possibility of interactions with heme, and this interaction on the other hand helped in predicting and differentiating the antibodies based on their functionality and molecular details. That was possible since these antibodies have higher hydrophobicity, intrinsic polyreactivity and self-binding propensity while lower expression yields.
More study on this field is deemed necessary since this heme-antibody interaction would not only bring to the limelight a proper understanding of these antibodies but would also help researchers to develop new ways of detection of the unwanted properties of candidate therapeutic antibodies and potentially even working to delete the same.
Also read: mRNA-1273 shows promising results after Phase 3 trial
Source: Lecerf M, Kanyavuz A, Rossini S, Dimitrov JD. (2020) Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities. bioRxiv. https://doi.org/10.1101/2020.08.04.236992
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