Can our immune system battle against Depression?

-Shrayana Ghosh, Amity University

A recent study conducted at Yale University compared the immune system cells in the spinal fluid of healthy people and people with Multiple Sclerosis (MS). It was reported that an inflammatory autoimmune response within the CNS (Central Nervous System) has been identified that is associated with neurodegenerative disorders such as MS.

The findings support a growing hypothesis that Gamma infernos modulate a range of immunological system responses that may also help in averting depression in a healthy person.

In earlier experiments, the blockage of T cells and Gamma interferons in mice produced depression-like characteristics.

With empowering technology, researchers can analyze individual cells in-depth, showing that, the functions of T cells in a healthy person’s spinal fluid are quite similar to those of MS patients. They however lack the potential to replicate, thus causing damaging inflammatory response like seen in MS.

Evidently, the immune system may also have a different role than protecting against pathogens.

Suggested article:

Gold SM, Irwin MR. Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. Neurol Clin. 2006;24(3):507-519. doi:http://10.1016/j.ncl.2006.03.007

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