Ananya Ghosal, MAKAUT(WB) The two main reasons for an increase in the application of Induced Pluripotent Stem Cells (iPSCs) are the development of organoids and differentiated cells. Few concerns like the pre-existing or reprogramming-related occurrence of tumorigenic mutations, the age-related burden of somatic mutation hamper the therapeutic use of iPSCs. Mitochondrial DNA (mtDNA) is an […]
Sayak Banerjee, Amity University Kolkata Intra-tumor Heterogeneity ( ITH) Aggregation of a distinct set of somatic mutations leads to the generation of tumors. The set of mutations assembled by the prime tumor is known as clonal and the mutations which take place in pre-existing tumors comprise cancer cell sub-populations is known as subclonal. Consequently, the […]
Ayooshi Mitra, Amity University Kolkata A genomic study of skin cells shows that there is a wide range of age-independent mutations in the normal number of somatic mutations that arise from exposure to UV light. The human skin is constantly subjected to damage of DNA due to the environment, which leads to the accumulation of […]
