Charvy Rana, Department of Pathology, AIIMS, New Delhi What is MYCN protein? Cancer often involves the inactivation of tumor-suppressor genes and/or over-activation of oncogenes. The MYCN proto-oncogene is one such example, implicated for its amplified or “oncogenic” status in several neuronal and non-neuronal cancers (those of lung, ovaries, prostate, and more)1. Normally expressed during the […]
Monika R, PSG College of Technology, Coimbatore Melanoma is a deadly skin cancer that is said to occur mainly because of the accumulation of mutations in growth-regulating genes, the loss of adhesion receptors, and the increase in autocrine and paracrine growth factors- all of which contribute to uncontrolled proliferation promoting the survival of those abnormal […]
Chitra Roy, University of Calcutta In 1965, a group of British oncologists viewed DNA fragments which were floating around chromosomes in cancer cells. For decades, there has been largely ignored as cellular debris. Recent advancements of technology in the field of genetics and cellular biology has paved a way for better understanding of complex diseases […]
