Parnad Basu, Amity University Kolkata What is Parkinson’s disease? Parkinson’s disease is a neurodegenerative disorder that affects neurons (dopamine-producing) of substantia nigra. Symptoms of this disease develop slowly over the years and vary from person to person. The cause of Parkinson’s disease is not well known which makes it difficult to cure. However, medications and […]
Husna, Amity University Kolkata α-synuclein (α-syn) are small cytoplasmic proteins found in the brain and are localized to presynaptic terminals which inhibit the release of neurotransmitters. α-synuclein (α-syn) aggregates or their inclusions accumulate in specific regions of the brain; this abnormal accumulation is a hallmark of synucleinopathies (a group of neurodegenerative diseases) like Parkinson’s disease […]
Sumedha B S, Bangalore University What is Ubiquitin? Ubiquitin is a small 76-amino acid protein found in eukaryotic cells. They are be found either freely or covalently bound to membrane proteins. It is one of the highly conserved proteins. This means its amino acid sequence is similar-from yeast to animals. It has two functional sites: […]
Priyanka Saha, Amity University Kolkata Introduction to prions Prions are infectious-disease causing agents which are mainly bits of misshapen proteins, more precisely referred to as “proteinaceous infectious particles”. After entering any living body, it misshapes the other proteins by deforming them during a sequence reaction until the brain is stuffed with holes like ‘Cheese’. Prions […]
