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May 15, 2025
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Tag: Mutation

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PHYSICS OF CANCER!

bioxone November 1, 2020November 1, 2020

Aakancha Shaw, St. Xavier’s College, Kolkata Isn’t cancer known to be a disease of the cell that is caused by the mutation of the genes that control proliferation and differentiation? Ever wondered what could be the physics of cancer? Recent observations have shown that the microenvironment (immediate small-scale environment) surrounding the cancer cell has a […]

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EFFECT OF MISSENSE VARIATIONs: REVELEALED

bioxone November 1, 2020November 1, 2020 2

DEEPON CHAKRABORTY, UNIVERSITY OF CALCUTTA Interpretation of a large number of genetic variants identified from sequencing is one of the breakthroughs of clinical genetics. It is also termed as genetic screening. The main challenge is the identification of the effect of amino acid substituting missense variation on protein structure and function. Its several applications are […]

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Genetic instability in Estrogen-exposed ovarian epithelium in association with ovarian cancer

bioxone October 25, 2020October 25, 2020

PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA Loss of genomic stability prejudice genomic consistency, genetic makeup, and promote malignancies. Pathological mutations of DNA repair genes result in ovarian-cancer (OvCa). The elevation of damage burden proportionates to the elevated estrogen level, inducing DNA lesions that are dependent on the expression of hormone-receptors in G1, G2, and S phase. […]

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Mutations associated with neuropsychiatric conditions contributing to psychiatric dysfunction

bioxone October 21, 2020October 20, 2020

PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA Mutation and copy number variants (CNV) are a great risk-factor for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD). But its association with functional brain connectivity (FC) is unknown. FC-changes may not surely represent an intermediate brain phenotype but a secondary impact of psychiatric illnesses. Individuals with a high […]

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COVID-19 TO BE NOTICED AS A COMBINATION OF VIRAL INFECTION AND AUTOIMMUNITY

bioxone October 9, 2020October 8, 2020

PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA A huge part of the population worldwide has been affected due to the deadly attack of the COVID19. As per close observations and studies, it is noted that the disease becomes fatal for few and mild for others. The spread of COVID-19 is a paradox of what causes the virus […]

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Nanomaterials to overcome microbial resistance?

bioxone October 9, 2020October 8, 2020

Prama Ghosh, Amity University Kolkata Increasing resistance to antibiotics by infectious microbes is emerging as a serious threat to mankind. To tackle this problem, nanomaterials are rapidly rising by improving the power of existing antibiotics or producing altogether new antibacterial instruments. An antibiotic works by inhibiting the synthesis of DNA, RNA or cell wall of […]

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Maharashtra: Palghar under alert due to rise of congo fever

bioxone September 29, 2020September 29, 2020

Devyani Goswami, Amity University  As if the devastation caused by the ongoing pandemic was not enough that the health officials of the National Center for Disease Control (NCDC) have confirmed four new cases of Crimean Congo Hemorrhagic Fever ( CCHF). Palghar, Maharashtra is under strict alert due to the same. India had earlier in 2011 […]

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Impact of α5 subunit gene in different stages of cocaine addiction

bioxone September 28, 2020September 27, 2020

-Parnad Basu, Amity University Kolkata Cocaine is a highly addicting substance, for which there is no effective treatment available. Frequent use of cocaine leads to massive health hazards even death. Cocaine primarily targets dopamine (a neurotransmitter associated with pleasure and reward) and increases its concentration. Cocaine can also act on the nicotinic receptors present in […]

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COVID UPDATE: Is COVID-3D taking us a step ahead towards a vaccine and drug development?

bioxone September 11, 2020September 11, 2020

– Richismita Hazra, Amity University Kolkata SARS-CoV-2 being a new pathogen, did not restrict itself to accumulate mutations across its genes. Researchers from the University of Melbourne, in Australia, developed a new software tool COVID-3D,  which proofs itself to be powerful enough for harnessing genomic and protein information about the virus and its mutations which […]

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Cancer is Genetic?

bioxone September 6, 2020September 6, 2020

-Sanket Roy, Amity University Kolkata Our life forms and progress depends upon the central dogma of life. DNA gets transcripted to RNA and RNA further translates Protein. The genetic code initiates and controls the growth and physiology of any cell.  Our body is made up of a community of individual cells having specific activities to […]

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Breaking News

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Exogenous Klotho as a Cognition Booster in Aging Primates

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