Threats to T-cell over-activation in response to CD28
PRAGYA SANTRA, AMITY UNIVERSITY Genome-wide association studies (GWAS) mapped the T-cell stimulatory pathways along with the CD28, CTLA4, and ICOS genes. GWAS studies and autoimmune disorders identified enriched chromatin regions as a consequence of memory T-cell over-activation. T-cell stimulation after occurring in the secondary lymphoid delivers two signals, first via T-cell receptors (TCR) to recognize […]