Role of lysosomes and α-synuclein fibrils in protein misfolding
Husna, Amity University Kolkata α-synuclein (α-syn) are small cytoplasmic proteins found in the brain and are localized to presynaptic terminals which inhibit the release of neurotransmitters. α-synuclein (α-syn) aggregates or their inclusions accumulate in specific regions of the brain; this abnormal accumulation is a hallmark of synucleinopathies (a group of neurodegenerative diseases) like Parkinson’s disease […]
