Hari Krishnan R, SRM Institute of Science and Technology Proteases are enzymes that break down proteins and perform very important functions in the body, including digestion, reducing inflammation. Cathepsins (CTS) are a group of lysosomal proteases that are found in almost all organisms and are essential for the normal metabolism of the body but also […]
Ayooshi Mitra, Amity University, Kolkata Mitochondrial alternative oxidase (AOX) is an enzyme that forms an integral part of the electron transport chain (ETS) in mitochondria. This enzyme is present in the mitochondria of many invertebrates. The expression of AOX in human mitochondria is regarded as a potential therapeutic strategy, regardless of the reason for the […]
Biswadeep Sen, Amity University Kolkata Recent studies show that Inflammation and Carcinogenic processes are interconnected. Not just because both induce DNA instability, but both are driven by the same pathways (like NF-kB, STAT3, mTOR and MAPKs). The pro-inflammatory cytokines like IL-6, IL-1β, TNF-α and IL-10 mould our immune responses and they are controlled by the […]
Rohit Bhattacharjee, Amity University Kolkata Acyl CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme A family that takes part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in tumour aggressiveness in breast and prostate tumours through various signal transduction pathways regulation. A well-validated ACSL4 inhibitor, however, has not been reported […]
Arjama Roy, Amity University Kolkata Endometrial cancer is the foremost common type of cancer that affects the feminine reproductive tract. It grows rapidly and tends to spread to other parts of the body. Earlier, the causative agent of endometrial carcinoma wasn’t known aside from the transcriptional effects of steroid hormones. As a result of which limited therapeutic options were provided to the diagnosed women. Recent work […]
