Richa Prakash, MSc, Central University of Punjab DNA or Deoxyribonucleic Acid is a complex molecular structure containing all the genetic information inside the cells required for the development and functioning of any organism. DNA damage occurs every day by the byproducts formed during cellular metabolism and ionizing radiations. DNA damage is any change in the […]
Avani Dave, Jai Hind College Ovarian cancer (OC) is among the most devastating gynaecological cancers, with high incidence and mortality rates across the world, putting women’s health and quality of life at risk. Although radical surgery and chemotherapy are two essential treatments for treating OC, they do not appear to diminish the high recurrence rate […]
Surupa Chakraborty, Amity University, Kolkata “The longer your telomeres, the better off you are”, remarkedElizabeth H. Blackburn, an eminent biologist and the Nobel Prize (2009) awardee for the remarkable discovery of how chromosomes are protected by telomeres and the enzyme telomerase. Insight into the fountain of youth: Telomeres are specialized minuscule molecular structures made from […]
Parnad Basu, Amity University Kolkata What is DSB? DNA DSB (double-strand break) is a cytotoxic lesion. It is caused by ionizing radiation and radio mimetic chemicals. It can also be caused by a replicative DNA polymerase encountering a DNA single-strand break or by mechanical stress on chromosomes. Sometimes two complementary strands of a double-helical DNA […]
Sayak Banerjee, Amity University Kolkata Many people have a wrong conception that since DNA damage can occur any time at any genomic site of a neuron, DNA repairs take place throughout the genome arbitrarily. Salk scientists have proved this view to be invalid saying that genomic sites are benefitted. Genomic sites are also known as […]
Souradip Mallick, National Institute of Technology, Rourkela DNA–protein crosslinks induce SOS response as it is mutagenic and 5-azacytidine induces bacterial damage and stimulate homologous recombination. All these consequences of DNA–protein crosslinks and 5-azacytidine were investigated on E.coli DNA–protein crosslinks (DPCs) are mainly formed when a nucleotide residue on DNA forms a covalent bond with a […]
