Richa Prakash, MSc, Central University of Punjab DNA or Deoxyribonucleic Acid is a complex molecular structure containing all the genetic information inside the cells required for the development and functioning of any organism. DNA damage occurs every day by the byproducts formed during cellular metabolism and ionizing radiations. DNA damage is any change in the […]
Sayak Banerjee, Amity University Kolkata Scientists have come over a class of drugs utilized in the treatment of breast and ovarian cancer which might be effective in other types of diseases with inadequate treatment alternatives. These are called PARP inhibitors which have the potential to kill cancer cells carrying a defect in the Polybromo 1(PBRM1) […]
Ayooshi Mitra, Amity University Kolkata A genomic study of skin cells shows that there is a wide range of age-independent mutations in the normal number of somatic mutations that arise from exposure to UV light. The human skin is constantly subjected to damage of DNA due to the environment, which leads to the accumulation of […]
Sayantani Halder,Amity University Kolkata Xeroderma Pigmentosum (XP) is a rare inherited human syndrome (recessive autosomal trait), caused due to the defect in mechanism of repairing of damaged DNA (or mutated DNA) characterized by hypersensitivity to sunlight, developing skin cancer at a very early age. The primary cause of this disease is the absence of a […]
PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA Loss of genomic stability prejudice genomic consistency, genetic makeup, and promote malignancies. Pathological mutations of DNA repair genes result in ovarian-cancer (OvCa). The elevation of damage burden proportionates to the elevated estrogen level, inducing DNA lesions that are dependent on the expression of hormone-receptors in G1, G2, and S phase. […]
