DEEPON CHAKRABORTY, UNIVERSITY OF CALCUTTA Interpretation of a large number of genetic variants identified from sequencing is one of the breakthroughs of clinical genetics. It is also termed as genetic screening. The main challenge is the identification of the effect of amino acid substituting missense variation on protein structure and function. Its several applications are […]
Rohit Bhattacharjee, Amity University, Kolkata Osteosarcoma is a rare malignant bone tumour found in adults and children. It is characterized by early lung metastasis and poor prognosis that seriously the physical and mental health of patients. Chemotherapy and surgery include the main clinical treatment however, recurrence of metastasis remains the poor prognosis. Advances in the […]
Avipsha Datta, Rajabazar Science College, University of Calcutta The Bcl-2 family of proteins are the prime players in the mitochondrial pathway of apoptosis. Malfunctioning of 1 or more members can lead to cancers, neurodegenerative diseases and various other developmental disorders. The pro-apoptotic member BAX plays a central role in apoptosis with the assistance of mitochondrial […]
Prama Ghosh, Amity University Kolkata An increased chance of cancer among those who consume large amounts of dairy products and red meat has been identified by a team of researchers at the Department of Cell Research and Immunology of Shmunis School of Biomedicine and Cancer Research at Tel Aviv University’s George S. Wise Faculty of […]
Chitra Roy, University of Calcutta In 1965, a group of British oncologists viewed DNA fragments which were floating around chromosomes in cancer cells. For decades, there has been largely ignored as cellular debris. Recent advancements of technology in the field of genetics and cellular biology has paved a way for better understanding of complex diseases […]
Arjama Roy, Amity University Kolkata Gastric adenocarcinoma is the 5th most typical cancer worldwide. The main risk factor for non-cardia gastric adenocarcinoma is atrophic gastritis. It is because of infection with Helicobacter pylori (H pylori). However, in Western populations, due to the decreasing pervasiveness of H pylori infections, the incidence of gastric adenocarcinoma has declined […]
PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA Loss of genomic stability prejudice genomic consistency, genetic makeup, and promote malignancies. Pathological mutations of DNA repair genes result in ovarian-cancer (OvCa). The elevation of damage burden proportionates to the elevated estrogen level, inducing DNA lesions that are dependent on the expression of hormone-receptors in G1, G2, and S phase. […]
Shreelekha Pore, National Institute of Technology, Rourkela 25% of non-Hodgkin Lymphoma includes Diffuse Large B-Cell Lymphoma (DLBCL). Through the study of cell-of-origin (COO) using gene expression profiling (GEP), DLBCL has been classified as- germinal centre B-cell-like and activated B-cell-like. Artificial intelligence is widely used for prognostic purposes for certain diseases. Machine Learning can be used […]
Chitra Roy, University of Calcutta Cancer Immunotherapy work by helping the immune system to function in an efficient manner to fight cancer cells. For the immune system to start its response, it must first be able to identify and differentiate between self-part of your own body and non-self-foreign/antigen. Cancer Immunotherapy is generally divided in two […]
Chitra Roy, University of Calcutta High-Grade Serous Ovarian Carcinoma (HGSOC) is one of the most common and deadliest types of ovarian cancer. This gynaecological malignancy is a type of tumour which arises from the ovary, fallopian tube, or peritoneum. The tumour microenvironment is very complex and 40% of this tumour mass contains Macrophages. Macrophages originate […]
