Aqsa Khan, Jamia Millia Islamia The History Behind The Warburg Effect In the 1920s, Otto Warburg described the increased production of lactate utilizing glucose even in an adequate supply of oxygen in tumor cells. Warburg, from his study, concluded that this impairment in cancer cells is due to dysfunctional mitochondria. Over a period, however, with […]
Sayak Banerjee, Amity University Kolkata Palmitoylation and PATs: Several proteins undergo post-translational modification via the addition of a lipid molecule on the amino acid cysteine through a thioester bond. This modification is termed palmitoylation and owing to the incorporation of variable lengths of lipid chains, it is also called S-acylation. Being a reversible lipid modification, […]
Agrima Bhatt, Rajasthan University Many cancer patients are responsive to chemotherapy at the initial stages of treatment. Although, during treatment, they may develop resistance which makes cancer difficult to diagnose. This is of huge clinical concern in such sensitive treatments as it can later convert into huge barricades in patient’s lives. In clinical cancer treatment, […]
Nandini Pharasi, Jaypee Institute of Information Technology What is neuroblastoma? Neuroblastoma is a condition in which malignant cells develop in the adrenal glands, neck, chest, or spinal cords neuroblasts (immature nerve tissue). A gene mutation (change) handed down from parent to kid can develop neuroblastoma. Neuroblastoma is responsible for 8–10% of all malignancies in children […]
Agrima Bhatt, Rajasthan University Oncological sciences have moved far in terms of research and development, leading to many novel therapies currently in use. Despite research on tumors and their causes, cancer remains the leading cause of death worldwide. The most popular approach to cancer treatment has been chemotherapy and radiation therapy. These approaches are not […]
Kanikah Mehndiratta, M.Sc., University of Glasgow Vitamin C, also called ascorbic acid, was the first vitamin to be artificially synthesized. It is one of the most essential micronutrients that plays a role in tissue repair and enzymatically producing many neurotransmitters. It is widely used to prevent diseases such as Scurvy. It has antioxidant properties and […]
Parnad Basu, Amity University Kolkata What is glioblastoma? When the cells of our body start to grow at a rapid speed and uncontrollably, a tumor is formed. A tumor can be both dangerous (malignant) and not dangerous (benign). In the case of malignant tumors, it tends to spread from one body part to the other […]
Shayan Ahmed, Jamia Millia Islamia, New Delhi What is Glioma? A glioma is a form of brain tumour that arises from glial cells. It can be divided into subgroups based on shape and histology, such as astrocytoma and glioblastoma. The World Health Organization (WHO) has classified glioma into four categories. Rapid cell growth and a […]
Husna, Amity University Kolkata What is K-Ras-CaM interaction? K-Ras is an oncogenic mutant that helps the cancer cells to proliferate, migrate, invade, and survive by assembling some signalling complexes. These complexes have a great therapeutic and mechanistic significance, however, to date, the functional and structural roles of K-Ras mutations within these complexes are not completely […]
Saptaparna Dasgupta, Bennett University Human exonuclease V (EXO5) is an ATR-regulated nuclease that is specific to the DNA structure. It is also associated with BLM, to mark the start point of the replication fork in a strand of DNA. Research states that an elevated level of EXO5 in tumor cells results in increased mutation within […]
