Janhavi Patil, Symbiosis School of Biological Sciences, Pune What is Schizophrenia? Many mental disorders are prevalent today. Considered a clinical syndrome, Schizophrenia is commonly diagnosed in people today. Disordered thinking, hallucinations, and inability to concentrate, express emotions and carry out daily chores are some common manifestations of this mental disorder. Disease diagnosis is given on […]
Sumedha B S, Bangalore University Xenobiotics: Xenobiotics are chemical substances that are foreign (extrinsic to the normal metabolism of an organism). These include- fragrances, drugs, pesticides, cosmetics, food additives, environmental pollutants, and industrial chemicals. It was found that humans are exposed to about 2 million xenobiotics in a lifetime. These chemicals gain access to the […]
Sayak Banerjee, Amity University Kolkata In the year 1977, the Archaebacteria or Archaea, the third domain of life separate from Bacteria and Eukaryota, was proposed by Carl Woese and George Fox. They had analyzed small subunit ribosomal RNA ( SSU rRNA) oligonucleotide fragments from 13 microbes before establishing this proposal. In the late 1980s, the use of SSU rRNA to describe […]
Madhavi Bhatia, National Institute of Pharmaceutical Education and Research Guwahati Taxonomy is a branch of science that classifies organisms into hierarchical forms based on their similar characteristics into various groups. There are various fields like metagenomics, clinical forensic medicine that depend on fully annotated taxonomic data for identification and grouping of organisms present within the […]
Saakshi Bangera, DY Patil School of Biotechnology and Bioinformatics Metabolomics is the study of metabolites in a biological sample. These studies enhance our understanding of the consequences of diet on metabolomic pathways. Intra and interindividual variations differ on various levels among metabolites. The metabolomic composition of biological fluids is influenced by numerous factors such as […]
Sumedha B S, Bangalore University Cyclin Proteins: The cell cycle is the sequence of processes that take place in a cell which ultimately leads to its division into two daughter cells. The mechanism of the cell cycle is regulated by a type of protein called “Cyclins”. Cyclins bind and activate cyclin-dependent kinases (CDKs). Cyclins were […]
Saakshi Bangera, DY Patil School of Biotechnology and Bioinformatics Copy number variation is the phenomenon of deviation of an individual from a diploid state of its genome. Normally, humans have two copies of each locus in their genome. Any deviation from this can cause Mendelian disorders. Due to the availability of short-read sequencing technologies, several […]
Saakshi Bangera, DY Patil School of Biotechnology and Bioinformatics Chemical modifications of nucleotide bases of RNA are important regulators of RNA metabolism. Detecting such modifications may revolutionize transcriptomics, but is equally challenging to develop. RNA profiling concerning the transcriptome is quite difficult due to the lack of effective technology. A solid detection and analysis technique […]
Saakshi Bangera, DY Patil School of Biotechnology and Bioinformatics Hepatitis C, caused by the Hepatitis C virus (HCV) is a worldwide disease with a prevalence rate of approximately 70 million infections. After an infection, the parenchymal cells produce a large number of interstitial lymphocytes. These lymphocytes stimulate the proliferation and differentiation of T helper cells. […]
Sayak Banerjee, Amity University Kolkata Intra-tumor Heterogeneity ( ITH) Aggregation of a distinct set of somatic mutations leads to the generation of tumors. The set of mutations assembled by the prime tumor is known as clonal and the mutations which take place in pre-existing tumors comprise cancer cell sub-populations is known as subclonal. Consequently, the […]
