Sumedha B S, Bangalore University What is Ubiquitin? Ubiquitin is a small 76-amino acid protein found in eukaryotic cells. They are be found either freely or covalently bound to membrane proteins. It is one of the highly conserved proteins. This means its amino acid sequence is similar-from yeast to animals. It has two functional sites: […]
Akash Singh, Banaras Hindu University Autophagy, often blamed for senescence, is a conserved process that promotes cellular homeostasis by degrading cytosolic components (sometimes referred to as cargo). This cargo sequestered into autophagosomes, which are double-membrane vesicles that are primarily carried in the retrograde direction to the perinuclear area, where they combine with lysosomes, ensuring cargo […]
Thota Kanishka Rao, Amity University Kolkata Prostate cancer growth (PCa) is the most common disease after skin disease and the subsequent driving reason for cancer death in men. Androgen receptor (AR) flagging is fundamental for PCa cell development and endurance. Hence, androgen development treatment (ADT) is the standard treatment for advanced/metastatic PCa. Notwithstanding, patients unavoidably […]
Shrayana Ghosh, Amity University Kolkata A research team from UT Southwestern has recognised a key gene necessary for cells to consume and destroy viruses. The findings which were reported in Nature could lead to ways that could manipulate this process to improve the immune system’s ability to combat viral infections. The key gene essential for cells […]
Richismita Hazra, Amity University Kolkata Macular degeneration is an eye disease that causes loss in the centre of the field of vision and often leads to irreversible blindness. The disease is broad of two types: dry macular degeneration in which there is a deterioration of the centre of the retina and wet macular degeneration that […]
Biswadeep Sen, Amity University Kolkata Recent studies show that Inflammation and Carcinogenic processes are interconnected. Not just because both induce DNA instability, but both are driven by the same pathways (like NF-kB, STAT3, mTOR and MAPKs). The pro-inflammatory cytokines like IL-6, IL-1β, TNF-α and IL-10 mould our immune responses and they are controlled by the […]
PRAGYA SANTRA, AMITY UNIVERSITY KOLKATA Normally osteocyte apoptosis is the default fate to remove dead bone cells and its self-renewal for preserving the strength. But at times the apoptosis gives rise to pathological conditions of ageing, fatigue, inflammation, decreased bone mineral density, ultimately bone loss. Osteocytes surgery often induces osteoporosis resulting in bone microstructure and […]
Team bioXone The regulatory effects of long non-coding RNAs (lncRNAs) in a range of developmental processes and diseases have generated tremendous attention from the scientific community worldwide. Although the exact knowledge of their action is limited, a small number of well-studied lncRNAs have provided clues about their biological functions and mechanisms. A well-studied novel lncRNA, […]
