Priyanka Saha, Amity University Kolkata Introduction It is well known that sleep is essential to the normal functioning of our bodies and for our health. After a tired and stressful day, the body needs to sleep for a minimum of 7 hours to regain its strength. But as we know, too much of anything is […]
Komal Bavaskar, D Y Patil University Alzheimer’s disease affects around 5.8 million Americans aged 65 and over. 80% of those surveyed are 75 or older. In India, more than 4 million people are affected by this disease. Alzheimer’s disease is thought to affect between 60% and 70% of the approximately 50 million individuals globally who […]
Sribas Chowdhury, Adamas University, Kolkata Neurodegenerative diseases like Alzheimer’s are some of the most complicated diseases existing amongst modern humankind. These diseases are often complicated to understand. And since their causative agents are unknown in 80% of cases, their treatment is even more challenging. Primarily, the reasons associated with AD were mainly centered around the […]
Priyanka Saha, Amity University Kolkata Introduction Senolytics are a special class of drugs that eliminate old or senescent cells (SC) in the body. They are developed to prevent or delay age-related diseases in humans. The word senolytics is connected to “Senostatic” which refers to suppressing senescence. Most of the senolytic agents are in the early […]
Anjali Kumari, IILM College of Engineering and Technology The international team of scientists in Sweden has discovered a new gene mutation that is linked to the early onset of the Alzheimer’s disease. This has been done by tracing the DNA flaw through various members of a single family. What is Alzheimer’s disease? Alzheimer’s also called […]
Ananya Ghosal, MAKAUT(WB) Protein Trafficking The transportation of proteins to the extracellular space or subcellular compartments is called protein trafficking. Protein quality control contains everything from monitoring protein folding, cellular mechanisms, to detecting abnormal forms. Firstly, proteins are synthesized at cytoplasmic ribosomes, and their destinations are determined by transport signals. Cytosolic proteins are those where […]
Kanikah Mehndiratta, MSc, University of Glasgow Alzheimer’s disease (AD) is a progressive neurodegenerative condition that causes brain atrophy or shrinking, ultimately leading to death of brain cells. It is considered to be the biggest cause of dementia globally. The death rate due to AD in U.S came out as 37 per 100,000 people in 2019. […]
Surupa Chakraborty, Amity University, Kolkata ‘I feel as if I’m losing all my leaves. The branches, and the wind, and the rain. I don’t know what’s happening anymore.’ This is the statement that reminds us of Anthony Hopkins’ accurate portrayal of a dementia patient in “The Father” (2020). And precisely, the movie attempts to put […]
Sayak Banerjee, Amity University Kolkata Palmitoylation and PATs: Several proteins undergo post-translational modification via the addition of a lipid molecule on the amino acid cysteine through a thioester bond. This modification is termed palmitoylation and owing to the incorporation of variable lengths of lipid chains, it is also called S-acylation. Being a reversible lipid modification, […]
Priyanka Saha, Amity University Kolkata Introduction to prions Prions are infectious-disease causing agents which are mainly bits of misshapen proteins, more precisely referred to as “proteinaceous infectious particles”. After entering any living body, it misshapes the other proteins by deforming them during a sequence reaction until the brain is stuffed with holes like ‘Cheese’. Prions […]
