Skip to content
Tagged COVID-19 Biotechnology SARS-CoV-2 Life Science cancer CORONAVIRUS pandemic
BioXone

BioXone

rethinking future

May 31, 2025
  • About
  • BiotechTodayNews
    • IndiaWeekly Biotech News of India
    • WorldWeekly Biotech News of The World
  • DNA-TalesArticles
    • BiotechnopediaInteresting articles written by BioXone members and associates.
    • Scientists’ CornerArticles from the pioneers of Biotechnology.
    • Cellular CommunicationInterview of greatest researchers’ in the field.
  • Myth-LysisFact Check
  • Signalling PathwayCareer related updates
    • ExaminationsExamination related articles.
    • Job and InternshipJobs and Internship related articles.
  • Courses
  • Contact

Most Viewed This Week

October 17, 2023October 16, 2023

The Corrosion Prediction from the Corrosion Product Performance

1
October 1, 2023September 30, 2023

Nitrogen Resilience in Waterlogged Soybean plants

2
September 28, 2023September 28, 2023

Cell Senescence in Type II Diabetes: Therapeutic Potential

3
September 26, 2023September 25, 2023

Transgene-Free Canker-Resistant Citrus sinensis with Cas12/RNP

4
September 25, 2023September 25, 2023

AI Literacy in Early Childhood Education: Challenges and Opportunities

5
September 22, 2023October 1, 2023

Sustainable Methanol Vapor Sensor Made with Molecularly Imprinted Polymer

6

Search Field

Subscribe Now

  • Home
  • BiotechToday
  • Interference of human microbiome with cancer therapeutics

Slipped capital femoral epiphysis and endocrinopathy

GATA3: Analyzing a transcription factor involved in ovarian cancer

Interference of human microbiome with cancer therapeutics
  • BiotechToday
  • World

Interference of human microbiome with cancer therapeutics

BioTech Today August 21, 2021August 20, 2021

Kanikah Mehndiratta, MSc, University of Glasgow

Human microbiome constitutes various microorganisms and their genomes, residing on the skin or inside organ systems. Inside the body, these microbes are known to be involved in many intricate metabolic pathways. This automatically gives them an opportunity to interfere in different diseases and their treatments.

Devising successful therapeutics against cancer has been a challenge for scientists. Studies have also reported association between response of a patient to a cancer treatment with his microbiome. Specific bacteria, fungi, viruses, and protozoans could be responsible for cancer treatment-related toxicity. However, not much is known about the kind of interaction that interferes with treatment efficacy/toxicity. To find answers in this field, a recent study published in the BMC Cancer journal is found to review the association of gut microbiome with different cancer therapies.

The gut microbiome

Trillions of microbes are interacting with host cells constantly at various sites in the body. The gut microbiome is an essential part of this community and is involved in modulation of various metabolic pathways. Residing in the gastrointestinal tract, an abnormality in their type or number, called Dysbiosis could result in various illnesses. That is why, many people emphasize the use of probiotics to maintain a healthy gut environment. These health issues do not pertain only to the digestive tract but also include neurological, respiratory, and metabolic illnesses.

Cancer has led to millions of deaths every year globally. Several researchers have identified the dominant role of the host’s immune system in carcinogenesis, cancer control, progression, and therapeutic responses. Mutational load, tumour metabolism, and sensitivity of tumour to immune effectors are considered tumour-centric markers when discussing the host’s response to treatment. But many other factors could be involved in a therapeutic response such as overall immune status and tumour microenvironment. An infiltration of immune cells with tumour cells could potentially be stimulatory or inhibitory in generation of immune responses. New studies are demonstrating mediation of treatment-related toxicity by changing constituents of the gut microbiome.

Interference of intra-tumour microbiota with immunity

Techniques such as NGS have helped identify specific microbial species and their abundance in patients undergoing cancer therapies. The study of interest here used PubMed, Embase and various other databases to review interference of the gut microbiota in tumour associated host’s immunity. It emphasizes on the utilization of immune checkpoint inhibitors (ICIs) while devising therapeutics against cancer. Monoclonal antibodies that target programmed death receptors, associated ligands, and cytotoxic T lymphocyte receptors could prove revolutionary in improving cancer prognosis.

Impact of gut microbiota in specific tumour response to ICIs has been reported in various preclinical mouse models. Same mouse strains but purchased from different sources, thus with different gut microbiomes, respond differently to ICI therapy against melanoma. Gut dysbiosis can also induce resistance to ICI therapy, affect its efficacy and potentially cause side-effects. Mice with healthier gut microbiomes exhibit better treatment efficacy.

The basis of interference in cancer therapy

The study concludes that interaction between the gut microbiome and the patient’s immune system could be the basis of interference with his cancer therapy. The review also concludes that in metastatic melanomas, Bacteriodetes act as biomarkers against ICI therapy. They can attenuate immunity against tumour and may decrease response rate. This could lead to lesser risk of ICI-induced colon inflammation. Other bacterial species such as Bacteroides caccae and B. thetaiotamicron would rather improve the effectiveness of an immune response. Much more substantial research is needed in the area in order to improve efficacy of treatments and counter associated side-effects.

Also read: Fetal membranes can heal themselves

References:

Yu, Z.-K., Xie, R.-L., You, R., Liu, Y.-P., Chen, X.-Y., Chen, M.-Y., & Huang, P.-Y. (2021). The role of the bacterial microbiome in the treatment of cancer. BMC Cancer, 21(1), 934. https://doi.org/10.1186/s12885-021-08664-0

2. Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018). The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell, 33(4), 570–580. https://doi.org/10.1016/j.ccell.2018.03.015

  • The Corrosion Prediction from the Corrosion Product Performance
  • Nitrogen Resilience in Waterlogged Soybean plants
  • Cell Senescence in Type II Diabetes: Therapeutic Potential
  • Transgene-Free Canker-Resistant Citrus sinensis with Cas12/RNP
  • AI Literacy in Early Childhood Education: Challenges and Opportunities

Author info:

Kanikah Mehndiratta is an avid researcher in the field of Genetics with a background in Biotechnology. She is a postgraduate from the University of Glasgow in their Medical Genetics and Genomics program. Currently, based in Chandigarh as a scientific writer, she involves herself mainly in projects related to neurological disorders. Outside of academics, she likes to read novels, travel and is involved in volunteer work mostly.

LinkedIn profile- https://www.linkedin.com/in/kanikah-mehndiratta-301830171

Other articles-

1. https://bioxone.in/news/worldnews/natural-killer-cells-defence-against-self-destruction/

2. https://bioxone.in/news/worldnews/crispr-cas9-for-disease-resistance-in-salmon/

3.https://bioxone.in/news/worldnews/sexually-dimorphic-hydrocarbons-pheromones-in-cockroaches/

Share this:

  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on X (Opens in new window) X

Related

Tagged cancer gut microbiome immune checkpoint inhibitors (ICIs) immune effectors Microbiota therapeutics treatment efficacy tumour microenvironment

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Next Post
  • BiotechToday
  • World

GATA3: Analyzing a transcription factor involved in ovarian cancer

bioxone August 22, 2021

Avani Dave, Jai Hind College Ovarian cancer (OC) is among the most devastating gynaecological cancers, with high incidence and mortality rates across the world, putting women’s health and quality of life at risk. Although radical surgery and chemotherapy are two essential treatments for treating OC, they do not appear to diminish the high recurrence rate […]

GATA3

Related Post

  • BiotechToday
  • World

Changes in our brain and body size linked to climate!

BioTech Today July 17, 2021July 17, 2021

Mustafa Vora, DY Patil University, Navi Mumbai In a recent study, a team of researchers compiled the measurements of brain and body size of over 300 fossils of Homo around the globe with the world’s regional climate over the last million years. This study showed how the size of the brain and body fluctuated over […]

Share this:

  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on X (Opens in new window) X
  • BiotechToday
  • World

Food Inhibiting Enzyme That Causes COVID Replication

bioxone December 8, 2020December 8, 2020

Thota Kanishka Rao, Amity University Kolkata Chemical compounds in some food or beverages, like green tea, muscadine grapes, and dark chocolate have been known to bind to and block the function of a protease, in the SARS-CoV-2 virus, according to researchers. Proteases are essential to the health and viability of cells and viruses. On the […]

Share this:

  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on X (Opens in new window) X
  • BiotechToday
  • India

Bharat Biotech’s Covaxin Gets International Validation

DNA tales August 8, 2021August 8, 2021

Sayak Banerjee, Amity University Kolkata Out of all the vaccine-making companies, Bharat Biotech is the only one to locally develop a vaccine in India and result in large-scale manufacturing. The manufacturing of Covaxin had been started at Ankleshwar, Gujarat before which equipment efficacy was studied by carrying out engineering batches. After a 120-day timeline for manufacturing, testing, release, regulatory […]

Share this:

  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on X (Opens in new window) X

Breaking News

The Corrosion Prediction from the Corrosion Product Performance

Nitrogen Resilience in Waterlogged Soybean plants

Cell Senescence in Type II Diabetes: Therapeutic Potential

Transgene-Free Canker-Resistant Citrus sinensis with Cas12/RNP

AI Literacy in Early Childhood Education: Challenges and Opportunities

Sustainable Methanol Vapor Sensor Made with Molecularly Imprinted Polymer

Exogenous Klotho as a Cognition Booster in Aging Primates

Terms and Conditions
Shipping and Delivery Policy
Cancellation and Refund Policy
Contact Us
Privacy Policy