– Prama Ghosh, Amity University Kolkata
Analysis of single cells is essential in order to study the molecular mechanisms of cellular functions. Recently, hidden molecular systems that lead to disease pathogenesis in patients is revealed – thanks to Single-cell genomics. Being a combination of technologies, it can uncover many hidden processes of biological systems.
Molecular pathology analysis of cardiac biopsy samples and isolation of single-cell RNA sequencing profiles of Cardiomyocytes – the principal component of heart, revealed the profiles of genes causing heart failure due to stress.
Integration of single cells articulation profiles of ligands and receptors in lung tissue, generated a communication map between cells, which recognized eosinophils as fundamental signal mediators in the lung. The observations also revealed an increment in the communications of endothelial cells during maturing.
In the days to come, approaches of single-cell genomics will prompt huge enhancements on biological research leading to improvements in treating patients worldwide.
Source: Nomura, S. Single-cell genomics to understand disease pathogenesis. J Hum Genet (2020). https://doi.org/10.1038/s10038-020-00844-3
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