Rohit Bhattacharjee, Amity University, Kolkata.
It has always been a critical challenge to establish an adequate vascularisation of 3D bioengineered tissues. A vascular scaffold using the vascular corrosion casting technique was fabricated earlier that provided a lookalike 3D geometry of native kidney vasculature. In this, the collagen vascular scaffold with the restricted release of VEGF (Vascular Endothelial Growth Factor) is functionalized to promote vascularisation. It showed improved angiogenic capability (the physiological process of formation of new blood cells from pre-existing cells) in 2D & 3D in vitro settings. VEGF vascular scaffold seeded with human renal cells implanted into a rat kidney demonstrated enhanced vascularisation & lower apoptosis rate of the implanted renal cells. Implanted human and migrated host renal cells formed hybrid renal tubule-like structures. This highlighted the instrumental role of early vascularisation of VEGF vascular scaffold mimicking the vascular scaffold in lowering apoptosis of implanted cells as well as the development of renal tissue structures.
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Source:-
Sangil Min, David Cleveland, In Kap Ko, Ji Hyun Kim, Hee Jo Yang, Anthony Atala, James J. Yoo, Accelerating neovascularization and kidney tissue formation with a 3D vascular scaffold capturing native vascular structure,Acta Biomaterialia, 2021,https://doi.org/10.1016/j.actbio.2021.01.040
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