Cholesterol used to recognize substrate by γ-Secretase
Shrestha Dutta, Amity University Kolkata γ-Secretase is an intramembraneaspartyl protease that is known to cleave various substrates inside its transmembrane region. It takes part in regulation of intramembrane proteolysis. It cleaves the signalling proteins inside their transmembrane domains (TMDs). The most noticeable instances of γ-secretase substrates consists of amyloid precursor protein (APP), connected to the growth […]