–Raddur Samaddar, Amity University Kolkata
Hypoxia is the talk of the town now, especially with the advent of COVID-19, curing of patients with severe levels of infection, escalating to respiratory problems, with oxygen-induced treatment is a major form of supportive care. Scientists have come up with a study that provides information on gut microbiota and their contribution to severe Hypoxia.
Up till now, we were confident about the fact that oxygen is the most important treatment ‘drug’ and any drug of choice has to be used in the correct dosage for treatment. The study has been performed with all the important parameters such as Comparative study with Human and Mice models, the dysbiosis in lungs, the correlations among hypoxia, the cecal microbiota composition, and alveolar inflammation with the antibiotic treatment and its effects. In untreated mice, treatment with excessive amounts of oxygen leads to a change in the mice’s microbiota, and a rise in the population of the Staphylococcus species was noted. It was inferred that such population alterations of the microbes were precursive to the onset of inflammation.
The aim of the study is to show how Hypoxia alters the microbiota growth conditions and also how a microbe-free environment is actually helping in the treatment. The harm we knew we were causing will be now proved from a therapeutic standpoint and we can alter the microbiota accordingly. Successive experiments would find out how such microbial manipulations would work.
Source: Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice. Ashley, S. L., Sjoding, M. W., Popova, A. P., Cui, T. X., Hoostal, M. J., Schmidt, T. M., Branton, W. R., Dieterle, M. G., Falkowski, N. R., Baker, J. M., Hinkle, K. J., Konopka, K. E., Erb-Downward, J. R., Huffnagle, G. B., & Dickson, R. P. (2020). Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aau9959,
JNU | JRF position |DBT funded Project
–Shristi Sharma, Amity University Kolkata Applications are invited for ONE Junior Research Fellow in the DBT funded project entitled “Study of in-depth genetic heterogeneity with respect to resistome and compensatory adaption of MDR Mtb clinical strains inside BM-Mesenchymal stem cells circulating in the North-East Region” in the laboratory of the undersigned. Salary: Rs.31,000/- per month + 24% HRA Essential Qualification: Post […]