Aakancha Shaw, St. Xavier’s College Kolkata
The classical functions of the skeleton are locomotion, protection and mineral homeostasis. In addition to the conventional structural functions of the skeleton, it has also functioned as a site for significant glucose uptake and is also involved in the regulation of whole-body glucose metabolism.
Recent observations have shown that the bone-specific phosphatase, Orphan 1 (PHOSPHO1), which is a prerequisite for bone mineralization is implicated in the regulation of energy metabolism in humans. An experiment concerning PHOSPHO1 mutant mice was performed. It was seen that PHOSPHO 1 mice exhibited improved basal glucose homeostasis and also resisted high-fat-diet-induced weight gain. Also, different methylation sites were identified in PHOSPHO 1 as potential biomarkers for the early detection of type 2 diabetes. Osteoblasts isolated from PHOSPHO 1 mice were found to be enriched with genes associated with glucose transport and insulin receptor signalling.
Hence, the study identified PHOSPHO1 as a potential therapeutic target for the treatment of obesity and diabetes.
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SOURCE: Suchacki, K.J., Morton, N.M., Vary, C. et al. PHOSPHO1 is a skeletal regulator of insulin resistance and obesity. BMC Biol 18, 149 (2020). https://doi.org/10.1186/s12915-020-00880-7
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