Arpita Adhikary, Amity University Kolkata
Deterioration of the respiratory system mainly the lungs is prominent in SARS COVID-19. An active agent, a jelly-like substance was found in dead COVID 19 patients’ respiratory system.
A novel fact is established by the researchers as they conducted an experiment comparing the diseased lung tissue of COVID patients and normal lung tissue. This experiment was done to identify the presence of jelly which is known as hyaluronan, a polysaccharide in the glycosaminoglycan group as hyaluronan can be a reason for respiratory inflammation and blockage.
So a group of researchers took autopsy of three lung tissue samples of COVID 19 patients and processed hyaluronan histochemistry along with a direct staining method to distinguish the presence of hyaluronan from normal lung tissues, stained by normal staining. This report confirms that hyaluronan presents in the form of exudates and plugs, obstructing the alveoli to perform. On the other side, Hyaluronan presents only in intact alveolar walls and perivascular tissue in the normal sample.
This up to date discovery can be used to find alternative effective therapies such as different enzymes which can be used to break hyaluronan.
Also read: Appendicitis – Antibiotics or Appendectomy?
Source: https://www.jbc.org/content/early/2020/09/25/jbc.AC120.015967
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