Anwita Sarkar, Team BioXone
Based on what we know so far about the complications of COVID-19, it frequently involves complications that bear similarities to autoimmune disorders. Up to now, there are little reports on possible IgA mediated autoimmune responses. A study was conducted to determine the association of COVID-19 with vigorous total IgA responses. It also aimed to determine the association of IgA antibodies with complications of severe illness. The most frequent event involves in severe COVID-19 is the thrombotic event which resembles the hypercoagulation of antiphospholipid syndrome (APS).
In this study, clinical data and antiphospholipid antibodies (aPL) production from 64 patients with COVID-19 were compared and reviewed from three independent tertiary hospitals. Clinical records obtained from the 64 patients with COVID-19 were divided into three categories: one with mild illness (mCOVID) (41%), another with a discovery cohort with severe illness (sdCOVID) (22%), and a confirmation cohort with severe illness (scCOVID) (38%). The total production of IgA, IgG, and aPL was measured.
Results revealed a significant association of severe illness with IgA production (sdCOVID, P=0.01; scCOVID, p-value<0.001) but not with total IgG production. Both cohorts with severe illness were significantly associated with elevated anti-Cardiolipin IgA, anti-Cardiolipin IgM, and anti-Beta2 Glycoprotein-1 IgA. Thus, a strong association was found between higher production of IgA and aPL with severe illness. This suggests triggering of a strong antiviral IgA response in bronchial mucosa, induces systemic autoimmunity.
Also read: mRNA-1273: A COVID vaccine for the old?
Source: Omar Hasan Ali, David Bomze, Lorenz Risch, Silvio D Brugger, Matthias Paprotny, Myriam Weber, Sarah Thiel, Lukas Kern, Werner C Albrich, Philipp Kohler, Christian R Kahlert, Pietro Vernazza, Philipp K Bühler, Reto A Schüpbach, Alejandro Gómez-Mejia, Alexandra M Popa, Andreas Bergthaler, Josef M Penninger, Lukas Flatz, Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies, Clinical Infectious Diseases, ciaa1496, https://doi.org/10.1093/cid/ciaa1496
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Raddur Samaddar, Team bioXone The pandemic is going about its length and breadth, in India, we have 9,43,990 active cases as of 2nd October 2020. The serological activity and also the cross-reactivity of the diseases are a major concern at this moment. A commercial SARS-CoV-2 ELISA test was used for patients diagnosed as Dengue, Zika, […]