Prama Ghosh, Amity University Kolkata
Severity and death from Coronavirus disease 2019 (Covid-19) are associated with the older population; testing such vaccine candidates is important to prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
A phase 1, open-label trial with an escalated dose of messenger RNA vaccine, mRNA-1273, which encodes the stabilized prefusion SARS-CoV-2 spike protein (S-2P) was conducted on 40 older adults (56 to >71 years). On receiving two doses of 25 μg or 100 μg of the vaccine for 28 days apart, adverse effects were mainly mild or moderate.
Shortly after the first immunization, binding-antibody responses rapidly increased. Higher binding- and neutralizing-antibody titers were induced in 100-μg dose than the 25-μg dose, thus, supporting the use of 100-μg dose in a phase 3 vaccine trial. Funded by the National Institute of Allergy and Infectious Diseases, the vaccine also elicited a strong CD4 cytokine response involving type 1 helper T cells.
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Source: Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults, Evan J.Anderson, M.D., Nadine G. Rouphael, M.D., Alicia T. Widge, M.D., Lisa A. Jackson, M.D., M.P.H., Paul C. Roberts, Ph.D., Mamodikoe Makhene, M.D., M.P.H., James D. Chappell, M.D., Ph.D., Mark R. Denison, M.D., Laura J. Stevens, M.S., Andrea J. Pruijssers, Ph.D., Adrian B. McDermott, Ph.D., Britta Flach, Ph.D., et al., for the mRNA-1273 Study Group
DOI: http://10.1056/NEJMoa2028436
https://www.nejm.org/doi/full/10.1056/NEJMoa2028436?query=RP
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