– Sagnik Nag, Amity University Kolkata
The human heart is a complex organ of the human body comprising of 4 distinct chambers. Cardiovascular ailments are the leading cause of death around the globe. Advanced research and insights on the epidemiology, etiology and mechanism of the ailment require an in-depth understanding of the physiological functioning of a healthy human heart. Adequate knowledge about the gene expression of the cardiac cells is an imperative step towards this endeavour.
Recently on 24 September’20 a team of researchers Monika Litviňuková et. al. researched upon this topic using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes. Single-cell and single-nucleus transcriptomics and smFISH enable the identification of physiological specificities, molecular signalling pathways, intercellular networks and spatial relationships by providing insight on coordinated communication of cardiac cells within their environment. The research presented the genetic sequencing and the transcriptomic data on six distinct regions of the heart, which is the highest up-to-date detailed research possible. FISH imaging technique was used to determine the spatial distribution of the selected cell lines.
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