–PRIYANKA CHAKRABORTY, AMITY UNIVERSITY KOLKATA
The foundation for the quest in vaccine discovery lies in antibodies and its immune response. Immunoglobulins (minute proteins) are the sole defenders against invading pathogens. Therefore, the detailed study of the immune system is a fascination around the globe.
Recently, Dr. Josef Penninger’s group at IMBA and UBC were amazed to witness the role of a new protein JAGN1 in the antibody production. A lab test on several mice, after excluding JAGN1 protein from B cells, showed a remarkable decrease in the production of antibodies along with changes in specific sugar structures.
Although JAGN1 was previously identified to cause a mutated disease, its’ actual gravity was unknown. Human immune system also showed a decrease in their antibody production in the absence of JAGN1 and hence the scientists concluded that this discovery will be important enough for a better understanding of the mechanism of antibody production and may prove to be potent enough for future vaccine development.
Citation:
Hagelkruys, A., et al. (2020) A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. Journal of Experimental Medicine. doi.org/10.1084/jem.20200559
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